MAGI2 Antibodies

AND MAGI2 ELISA kits, MAGI2 Proteins

Many biological assays use antibodies to detect MAGI2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAGI2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAGI2 antibodies...

We validate the specificity of these antibodies to MAGI2 by testing them on tissues known to express MAGI2 positively and negatively. Browse below to find the MAGI2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAGI2 Infographic by Boster Bio

All MAGI2 Products

Product

Figures

Specificity

Applications

Price

Anti-MAGI2 Antibody

13 Q&As

Human, Mouse, Rat

$360
Cat # A04546-1
100 µl

AIP1 (MAGI2) (NM_012301) Human Over-expression Lysate

Human

$960
Cat # LS009863
100 µg

MAGI2 Overview

Facts about Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2.

MAGI2 3D structure. Source: alphafold

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2)

Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells.

Enhances the ability of PTEN to curb AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.

Gene Information

Human
Gene Name:	MAGI2
Uniprot:	Q86UL8
Entrez:	9863

Family

Belongs to:

MAGUK family

Alternative Names

ACVRINP1; ACVRIP1; AIP1; AIP1AIP-1; ARIP1; atrophin 1 interacting protein 1; atrophin-1 interacting protein A; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; KIAA0705activin receptor interacting protein 1; MAGI2; MAGI-2SSCAM; membrane associated guanylate kinase, WW and PDZ domain containing 2; Membrane-associated guanylate kinase inverted 2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; SSCAM

Molecular Weight

Mass (kDA):
158.754 kDA

Genomic Context


Human

Location:	7q21.11
Sequence:	7; NC_000007.14 (78017055..79453667, complement)

Tissue Specificity

Specifically expressed in brain.

Subcellular Localizations

Cytoplasm. Late endosome. Cell junction, synapse, synaptosome. Cell membrane; Peripheral membrane protein. Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity).

Diseases

Neoplasms
Malignant Neoplasms
Infantile Spasms
Tissue Adhesions
Spasm
Intestinal Diseases
Ulcer
Schizophrenia
Inflammatory Bowel Diseases
Celiac Disease
Epilepsy
Colitis
Ulcerative Colitis

Encephalopathies
Hiv Infections
Liver Carcinoma
Mental Disorders
Prostatic Neoplasms
Malignant Neoplasm Of Prostate
Autistic Disorder

Interacting Proteins

ADRB1

Pathways

Localization
Pathogenesis
Transport
Cell Adhesion
Cell Growth
Cell Migration
Neurogenesis
Synaptic Vesicle Transport
Cell Division
Response To Tumor Necrosis Factor
Mrna Splicing
Translation
Cell Motility

Segmentation
Nuclear Import
Cell-cell Signaling
Vesicle Transport
Synaptic Transmission
Regulation Of Receptor Internalization
Endocytosis

PTMs

Phosphorylation

Dephosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAGI2

References

PMID: 9647693 by Wood J.D., et al. Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.

PMID: 10760291 by Wu X., et al. Evidence for regulation of the PTEN tumor suppressor by a membrane- localized multi-PDZ domain containing scaffold protein MAGI-2.