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- Table of Contents
1 Citations 6 Q&As
1 Citations 7 Q&As
Facts about Lymphatic vessel endothelial hyaluronic acid receptor 1.
May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for following re-uptake and degradation in lymph nodes. .
Human | |
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Gene Name: | LYVE1 |
Uniprot: | Q9Y5Y7 |
Entrez: | 10894 |
Belongs to: |
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No superfamily |
cell surface retention sequence binding protein-1; Cell surface retention sequence-binding protein 1; CRSBP1; CRSBP-1; extracellular link domain containing 1; extracellular link domain-containing 1; Extracellular link domain-containing protein 1; HAR; Hyaluronic acid receptor; lymphatic vessel endothelial hyaluronan receptor 1; lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE1; LYVE-1; LYVE-1XLKD1; XLKD1
Mass (kDA):
35.213 kDA
Human | |
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Location: | 11p15.4 |
Sequence: | 11; NC_000011.10 (10556966..10568665, complement) |
Mainly expressed in endothelial cells lining lymphatic vessels.
Membrane; Single-pass type I membrane protein. Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
PMID: 10037799 by Banerji S., et al. LYVE-1, a new homologue of the CD44 glycoprotein is a lymph-specific receptor for hyaluronan.
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