LSM6 Antibodies

AND LSM6 ELISA kits, LSM6 Proteins

Many biological assays use antibodies to detect LSM6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LSM6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LSM6 antibodies...

We validate the specificity of these antibodies to LSM6 by testing them on tissues known to express LSM6 positively and negatively. Browse below to find the LSM6 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LSM6 Infographic by Boster Bio

All LSM6 Products

Product

Figures

Specificity

Applications

Price

LSM6 (NM_007080) Human Recombinant Protein

$1249
Cat # PROTP62312
20 µg

LSM6 (NM_007080) Human Over-expression Lysate

Human

$628
Cat # LS011157
100 µg

LSM6 Overview

Facts about U6 snRNA-associated Sm-like protein LSm6.

LSM6 3D structure. Source: alphafold

U6 snRNA-associated Sm-like protein LSm6 (LSM6)

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1- LSM7 complex, which is believed to be involved in mRNA degradation by activating the decapping step from the 5'-to-3' mRNA decay pathway (Probable).

Gene Information

Human
Gene Name:	LSM6
Uniprot:	P62312
Entrez:	11157

Family

Belongs to:

snRNP Sm proteins family

Alternative Names

LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae); Sm protein F; U6 snRNA-associated Sm-like protein LSm6; YDR378C

Molecular Weight

Mass (kDA):
9.128 kDA

Genomic Context


Human

Location:	4q31.22
Sequence:	4; NC_000004.12 (146175703..146204436)

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Arthritis
Azoospermia
Chromosomal Translocation
Muscular Atrophy
Atrophy
Rheumatoid Arthritis
Primary Hypogonadism

Spinal Muscular Atrophy
Hypogonadism

Interacting Proteins

CLNS1A
LSM1
LSM2
LSM3
LSM5

LSM7
LSM8
SDCBP
SNRPD2

Pathways

Rna Processing
Cell Proliferation
Fermentation
Jak-stat Cascade
Localization

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LSM6

References

PMID: 10369684 by Salgado-Garrido J., et al. Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.

PMID: 10523320 by Achsel T., et al. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.