LSM4 Antibodies

AND LSM4 ELISA kits, LSM4 Proteins

Many biological assays use antibodies to detect LSM4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LSM4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LSM4 antibodies...

We validate the specificity of these antibodies to LSM4 by testing them on tissues known to express LSM4 positively and negatively. Browse below to find the LSM4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LSM4 Infographic by Boster Bio

All LSM4 Products

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Specificity

Applications

Price

Human LSM4 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9Y4Z0
Starting from 20ug

LSM4 (NM_012321) Human Over-expression Lysate

Human

$628
Cat # LS025804
100 µg

LSM4 Overview

Facts about U6 snRNA-associated Sm-like protein LSm4.

LSM4 3D structure. Source: alphafold

U6 snRNA-associated Sm-like protein LSm4 (LSM4)

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Gene Information

Human
Gene Name:	LSM4
Uniprot:	Q9Y4Z0
Entrez:	25804

Family

Belongs to:

snRNP Sm proteins family

Alternative Names

Glycine-rich protein; GRP; LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); U6 snRNA-associated Sm-like protein LSm4; YER112W

Molecular Weight

Mass (kDA):
15.35 kDA

Genomic Context


Human

Location:	19p13.11
Sequence:	19; NC_000019.10 (18306236..18323076, complement)

Subcellular Localizations

Nucleus.

Diseases

Edema
Spinal Muscular Atrophy
Muscular Atrophy
Atrophy
Infarction
Neurodegenerative Disorders
Infectious Mononucleosis
Ataxia
Fibrolamellar Carcinoma
Myocardial Infarction
Malignant Neoplasms
Metastatic Prostate Cancer
Cerebrovascular Accident

Lupus Erythematosus, Systemic
Adenocarcinoma
Malignant Neoplasm Of Prostate
Epstein-barr Virus Infections
Liver Carcinoma
Autoimmune Diseases Of The Nervous System
Fetal Death

Interacting Proteins

CALCOCO2
IKZF1
L3MBTL3
LSM1
LSM7

LSM8
PSTPIP1
ZBTB10

Pathways

Translation
Cell Cycle
Mrna Processing
Rna Processing
Transport
Aging
Localization
Rna Splicing
Methylation
Ribosome Biogenesis
Cell Death
Rna Interference
Hypersensitivity

Neurogenesis
Histone Modification
Snorna Processing
Embryo Development
Mrna Splicing
Mrna Stabilization
Chromatin Remodeling

PTMs

Methylation

Phosphorylation

Research Areas

Core ESC-Like Genes
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LSM4

References

PMID: 10369684 by Salgado-Garrido J., et al. Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.

PMID: 10523320 by Achsel T., et al. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.