Lnx1 Antibodies

AND Lnx1 ELISA kits, Lnx1 Proteins

Many biological assays use antibodies to detect Lnx1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Lnx1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Lnx1 antibodies...

We validate the specificity of these antibodies to Lnx1 by testing them on tissues known to express Lnx1 positively and negatively. Browse below to find the Lnx1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Lnx1 Infographic by Boster Bio

All Lnx1 Products

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Specificity

Applications

Price

Anti-LNX1 Mouse Monoclonal Antibody [Clone ID: OTI1H9]

Human, Mouse, Rat

$523
Cat # M06813
100 µl

LNX1 (NM_032622) Human Over-expression Lysate

Human

$628
Cat # LS084708
100 µg

Lnx1 Overview

Facts about E3 ubiquitin-protein ligase LNX.

E3 ubiquitin-protein ligase LNX (Lnx1)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. .

Gene Information

Mouse
Gene Name:	Lnx1
Uniprot:	O70263
Entrez:	16924

Family

Belongs to:

No superfamily

Alternative Names

EC 6.3.2.-; ligand of numb-protein X 1ligand of numb-protein X; LNXmulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX; MPDZ; Numb-binding protein 1; PDZ domain-containing ring finger protein 2; PDZRN2E3 ubiquitin-protein ligase LNX

Molecular Weight

Mass (kDA):
80.157 kDA

Genomic Context


Mouse

Location:	5\|5 C3.3
Sequence:	5;

Tissue Specificity

Isoform 1 and isoform 2 are expressed in the heart. Isoform 1 is also expressed in kidney, lung and skeletal muscle while isoform 2 is also expressed in brain.

Diseases

Neoplasms
Cell Transformation, Neoplastic
Glioma
Brain Neoplasms
Nervousness
Nervous System Neoplasms
Granuloma
Cell Invasion
Glioblastoma Multiforme
Melanoma
Q Fever
Tumor Progression
Acute Q Fever

Chronic Q Fever
Glioblastoma
Oligodendroglioma
Anaplastic Astrocytoma
Tissue Adhesions
Sarcoma
Immunologic Deficiency Syndromes

Pathways

Localization
Cell Fate Determination
Endocytosis
Neurogenesis
Rna Interference
Transport
Cell Adhesion
Cell Proliferation
Proteolysis
Immune Response
Spermatid Differentiation
Cell Cycle Arrest

Cell Division
Regeneration
Asymmetric Cell Division
Translation
Regulation Of Cell Shape
Cell Cycle

PTMs

Phosphorylation

Ubiquitination

Research Areas

Cancer
Hypoxia
Lipid and Metabolism
Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Lnx1

References

PMID: 9535908 by Dho S.E., et al. The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain- containing numb binding protein, LNX.

PMID: 11782429 by Nie J., et al. LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation.