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Protein lin-28 homolog A Antibodies
AND LIN28A ELISA kits, Protein lin-28 homolog A Proteins
Many biological assays use antibodies to detect Protein lin-28 homolog A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein lin-28 homolog A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein lin-28 homolog A antibodies...
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LIN28A Infographic by Boster Bio
All LIN28A Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01966-1
100 μl
Cat # M01966-1
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A01966-2
100 μg/vial
Cat # A01966-2
100 μg/vial
LIN28A Overview
Facts about Protein lin-28 homolog A.
Protein lin-28 homolog A (LIN28A)
RNA-binding protein which inhibits processing of pre-let- 7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Appears to recognize a common structural G- quartet (G4) feature in its own miRNA and mRNA targets (Probable).
'Translational enhancer' that compels specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization.
Gene Information
| Human | |
|---|---|
| Gene Name: | LIN28A |
| Uniprot: | Q9H9Z2 |
| Entrez: | 79727 |
Family
| Belongs to: |
|---|
| lin-28 family |
Alternative Names
CSDD1; CSDD1lin-28A; FLJ12457; lin-28 homolog (C. elegans); lin-28 homolog A (C. elegans); LIN28; LIN-28; LIN28A; LIN-28A; LIN28RNA-binding protein LIN-28; Tex17; ZCCHC1; ZCCHC1protein lin-28 homolog A; Zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
Molecular Weight
Mass (kDA):
22.743 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.11 |
| Sequence: | 1; NC_000001.11 (26410778..26429728) |
Tissue Specificity
Expressed in embryonic stem cells, placenta and testis. Tends to be up-regulated in HER2-overexpressing breast tumors.
Subcellular Localizations
Cytoplasm. Rough endoplasmic reticulum. Cytoplasm, P-body. Cytoplasm, Stress granule. Nucleus, nucleolus. Predominantly cytoplasmic (PubMed:22118463). In the cytoplasm, localizes to peri-endoplasmic reticulum regions and detected in the microsomal fraction derived from rough endoplasmic reticulum (RER) following subcellular fractionation. May be bound to the cytosolic surface of RER on which ER-associated mRNAs are translated (By similarity). Shuttle from the nucleus to the cytoplasm requires RNA-binding (PubMed:17617744). Nucleolar localization is observed in 10-15% of the nuclei in different
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Diabetes Mellitus
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Mammary Neoplasms
- Insulin Sensitivity
- Neoplasm Metastasis
- Embryonal Carcinoma
- Malignant Tumor Of Colon
- Carcinoma
Pathways
- Cell Cycle
- Menarche
- Translation
- Transport
- Organic Acid Transport
- Aging
- Embryo Development
- Cell Division
- Cell Morphogenesis Involved In Differentiation
- Invasive Growth
- Placenta Development
- Cell Morphogenesis
- Gonad Development
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LIN28A
bosterbio.com/bosterbio-gene-info-cards/LIN28A
References
PMID: 12798299 by Moss E.G., et al. Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites.
PMID: 15003116 by Sempere L.F., et al. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation.