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- Table of Contents
Facts about Partner and localizer of BRCA2.
Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the creation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211).
Human | |
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Gene Name: | PALB2 |
Uniprot: | Q86YC2 |
Entrez: | 79728 |
Belongs to: |
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No superfamily |
DKFZp667I166; DKFZp686E1054; FANCNFLJ21816; partner and localizer of BRCA2; PNCA3
Mass (kDA):
131.295 kDA
Human | |
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Location: | 16p12.2 |
Sequence: | 16; NC_000016.10 (23603162..23641337, complement) |
Nucleus. Colocalizes with BRCA2 and BRCA1 in nuclear foci.
PMID: 16793542 by Xia B., et al. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.
PMID: 17287723 by Erkko H., et al. A recurrent mutation in PALB2 in Finnish cancer families.