Partner and localizer of BRCA2 (PALB2)

Plays a crucial role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19423707, PubMed:19369211, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a tumultuous BRC3-BRC4 polypeptide and aids RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615).

Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the creation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211).