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LIMD1 Antibodies
AND LIMD1 ELISA kits, LIMD1 Proteins
Many biological assays use antibodies to detect LIMD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LIMD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LIMD1 antibodies...
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LIMD1 Overview
Facts about LIM domain-containing protein 1.
LIM domain-containing protein 1 (LIMD1)
Adapter or scaffold protein which participates in the assembly of many protein complexes and is involved in several cellular processes like cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is crucial for P-body formation and integrity.
Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.
Gene Information
| Human | |
|---|---|
| Gene Name: | LIMD1 |
| Uniprot: | Q9UGP4 |
| Entrez: | 8994 |
Family
| Belongs to: |
|---|
| zyxin/ajuba family |
Alternative Names
LIM domain-containing protein 1; LIM domains containing 1; LIMD1
Molecular Weight
Mass (kDA):
72.19 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.31 |
| Sequence: | 3; NC_000003.12 (45594105..45686341) |
Tissue Specificity
Expressed in normal and breast cancer tissues (at protein level). Ubiquitous.
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal adhesion. Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions. Down-regulation and/or elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient prognosis.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Tissue Adhesions
- Malignant Neoplasm Of Lung
- Dysplasia
- Retinoblastoma
- Von Hippel-lindau Syndrome
- Mammary Neoplasms
- Malignant Squamous Cell Neoplasm
- Malignant Neoplasm Of Breast
- Head And Neck Carcinoma
Pathways
- Cell Adhesion
- Methylation
- Cell Cycle
- Gene Silencing
- Regulation Of Cell Adhesion
- Mitosis
- Osteoclast Differentiation
- Epithelial Cell-cell Adhesion
- Osteoclast Development
- Cell Migration
- Osteoblast Differentiation
- Induction Of Apoptosis
- Osteoblast Development
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LIMD1
bosterbio.com/bosterbio-gene-info-cards/LIMD1
References
PMID: 10647888 by Kiss H., et al. A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3.
PMID: 11352561 by Kiss H., et al. The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3.