Kalirin Antibodies

AND KALRN ELISA kits, Kalirin Proteins

Many biological assays use antibodies to detect Kalirin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kalirin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kalirin antibodies...

We validate the specificity of these antibodies to Kalirin by testing them on tissues known to express KALRN positively and negatively. Browse below to find the KALRN antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KALRN Infographic by Boster Bio

All KALRN Products

Product

Figures

Specificity

Applications

Price

Anti-Kalirin KALRN Antibody

Human, Mouse, Rat

ICC, WB

$405
Cat # A04076
100ul

KALRN (NM_007064) Human Over-expression Lysate

Human

$960
Cat # LS008997
100 µg

KALRN Overview

Facts about Kalirin.

Kalirin (KALRN)

Promotes the exchange of GDP by GTP.
Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton.

Induces lamellipodia independent of its GEF activity. .

Gene Information

Human
Gene Name:	KALRN
Uniprot:	O60229
Entrez:	8997

Family

Belongs to:

protein kinase superfamily

Alternative Names

ARHGEF24; DUETFLJ16443; DUO; EC 2.7.11.1; FLJ12332; FLJ18623; HAPIP; huntingtin-associated protein interacting protein (duo); Huntingtin-associated protein-interacting protein; kalirin; kalirin, RhoGEF kinase; Protein Duo; serine/threonine kinase with Dbl- and pleckstrin homology domains; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; TRADFLJ18196

Molecular Weight

Mass (kDA):
340.261 kDA

Genomic Context


Human

Location:	3q21.1-q21.2
Sequence:	3; NC_000003.12 (124033341..124726325)

Tissue Specificity

Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton. Associated with the cytoskeleton.

Diseases

Schizophrenia
Alzheimer's Disease
Coronary Artery Disease
Cerebrovascular Accident
Ischemic Stroke
Brain Ischemia
Impairment (finding)
Huntington Disease
Infarction
Neurodegenerative Disorders
Hyperlipoproteinemia Type Iib
Immunologic Deficiency Syndromes

Myocardial Infarction
Cardiovascular Diseases
Attention Deficit Hyperactivity Disorder
Atherosclerosis Of Aorta
Epilepsy, Temporal Lobe
Nerve Degeneration

Pathways

Pathogenesis
Synaptic Transmission
Cognition
Cell Adhesion
Cell Division
Axon Guidance
Response To Cocaine
Brain Development

Dendritic Spine Maintenance
Dendritic Spine Development
Dendritic Spine Morphogenesis

PTMs

Phosphorylation

Cleavage

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KALRN

References

PMID: 9285789 by Colomer V., et al. Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.

PMID: 10023074 by Kawai T., et al. Duet is a novel serine/threonine kinase with Dbl-homology (DH) and pleckstrin-homology (PH) domains.