LARGE1 Antibodies

AND LARGE1 ELISA kits, LARGE1 Proteins

Many biological assays use antibodies to detect LARGE1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LARGE1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LARGE1 antibodies...

We validate the specificity of these antibodies to LARGE1 by testing them on tissues known to express LARGE1 positively and negatively. Browse below to find the LARGE1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LARGE1 Infographic by Boster Bio

All LARGE1 Products

Product

Figures

Specificity

Applications

Price

Anti-LARGE1 Purified Monoclonal Antibody

Human

Flow Cytometry, WB

$326
Cat # M32176
0.1 mg

LARGE (LARGE1) (NM_004737) Human Over-expression Lysate

Human

$960
Cat # LS009215
100 µg

LARGE1 Overview

Facts about LARGE xylosyl- and glucuronyltransferase 1.

LARGE1 3D structure. Source: alphafold

LARGE xylosyl- and glucuronyltransferase 1 (LARGE1)

Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays an integral role in skeletal muscle function and regeneration.

LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by incorporating repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699). .

Gene Information

Human
Gene Name:	LARGE1
Uniprot:	O95461
Entrez:	9215

Family

Belongs to:

No superfamily

Alternative Names

LARGE xylosyl- and glucuronyltransferase 1

Molecular Weight

Mass (kDA):
88.066 kDA

Genomic Context


Human

Location:	22q12.3
Sequence:	22; NC_000022.11 (33162237..33922824, complement)

Tissue Specificity

Ubiquitous. Highest expression in heart, brain and skeletal muscle.

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein.

Diseases

Muscular dystrophy-dystroglycanopathy congenital with mental retardation B6 (MDDGB6)

Interacting Proteins

B4GAT1

PTMs

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LARGE1

References

PMID: 9892679 by Peyrard M., et al. The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family.

PMID: 15752776 by Fujimura K., et al. LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE.