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VAPA Antibodies
AND VAPA ELISA kits, VAPA Proteins
Many biological assays use antibodies to detect VAPA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VAPA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VAPA antibodies...
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VAPA Infographic by Boster Bio
All VAPA Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M05329
100 µl
Cat # M05329
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05329-1
100 μg/vial
Cat # A05329-1
100 μg/vial
VAPA Overview
Facts about Vesicle-associated membrane protein-associated protein A.
Vesicle-associated membrane protein-associated protein A (VAPA)
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204).
With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470).
Gene Information
| Human | |
|---|---|
| Gene Name: | VAPA |
| Uniprot: | Q9P0L0 |
| Entrez: | 9218 |
Family
| Belongs to: |
|---|
| VAMP-associated protein (VAP) (TC 9.B.17) family |
Alternative Names
hVAP-33; MGC3745,33 kDa VAMP-associated protein; VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; VAMP-A; VAP-33; VAP33VAMP (vesicle-associated membrane protein)-associated protein A (33kD); VAPA; VAP-A; VAP-AVAMP-associated protein A; vesicle-associated membrane protein-associated protein A
Molecular Weight
Mass (kDA):
27.893 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18p11.22 |
| Sequence: | 18; NC_000018.10 (9914016..9960021) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Cell junction, tight junction. Nucleus membrane. Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells.
Diseases
- Actinomycetales Infections
- Pneumonia
- Horse Diseases
- Leukemia, Myelocytic, Acute
- Leukemia
- Hepatitis
- Hepatitis C
- Amyotrophic Lateral Sclerosis
- Sclerosis
- Primary Lateral Sclerosis
- Myeloid Leukemia
- Fish Diseases
- Gram-negative Bacterial Infections
Interacting Proteins
- APOD
- EGFR
- OPRM1
- OSBP
- OSBPL2
- RSAD2
- VAPB
- YIF1A
- ZFYVE27
Pathways
- Virulence
- Transport
- Exocytosis
- Lipid Transport
- Localization
- Pathogenesis
- Viral Replication
- Ceramide Transport
- Phagocytosis
- Immune Response
- Tropism
- Translation
- Vesicle Targeting
PTMs
- Cleavage
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VAPA
bosterbio.com/bosterbio-gene-info-cards/VAPA
References
PMID: 10523508 by Lapierre L.A., et al. VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction.
PMID: 9657962 by Weir M.L., et al. Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP.