Kelch domain-containing protein 8B (Klhdc8b)

Involved in pinching off the separated nuclei in the cleavage furrow and in cytokinesis. Required for mitotic ethics and maintenance of chromosomal stability.

Protects cells from mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation to the daughter cells.