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- Table of Contents
Facts about Krueppel-like factor 1.
Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Moreover, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes.
Human | |
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Gene Name: | KLF1 |
Uniprot: | Q13351 |
Entrez: | 10661 |
Belongs to: |
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krueppel C2H2-type zinc-finger protein family |
EKLFerythroid-specific transcription factor EKLF; Erythroid krueppel-like transcription factor; erythroid Kruppel-like factor; HBFQTL6; INLU; Krueppel-like factor 1; Kruppel-like factor 1 (erythroid); monoclonal A3D8
Mass (kDA):
38.221 kDA
Human | |
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Location: | 19p13.13 |
Sequence: | 19; NC_000019.10 (12884422..12887201, complement) |
Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.
Nucleus. Colocalizes with SUMO1 in nuclear speckles.
PMID: 8924208 by Bieker J.J.; Isolation, genomic structure, and expression of human erythroid Kruppel-like factor (EKLF).
PMID: 9119377 by van Ree J.H., et al. The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13.