Kinetochore scaffold 1 Antibodies

AND KNL1 ELISA kits, Kinetochore scaffold 1 Proteins

Many biological assays use antibodies to detect Kinetochore scaffold 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kinetochore scaffold 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kinetochore scaffold 1 antibodies...

We validate the specificity of these antibodies to Kinetochore scaffold 1 by testing them on tissues known to express KNL1 positively and negatively. Browse below to find the KNL1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KNL1 Infographic by Boster Bio

All KNL1 Products

Product

Figures

Specificity

Applications

Price

Anti-CASC5 KNL1 Antibody

Human, Rat

IF, IHC, ICC, WB

$405
Cat # A32138
100ul

KNL1 Overview

Facts about Kinetochore scaffold 1.

KNL1 3D structure. Source: alphafold

Kinetochore scaffold 1 (KNL1)

Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules.

Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complicated, which may be essential for kinetochore formation and proper chromosome segregation during mitosis.

Gene Information

Human
Gene Name:	KNL1
Uniprot:	Q8NG31
Entrez:	57082

Family

Belongs to:

No superfamily

Alternative Names

Kinetochore scaffold 1

Molecular Weight

Mass (kDA):
265.391 kDA

Genomic Context


Human

Location:	15q15.1
Sequence:	15; NC_000015.10 (40594012..40664342)

Tissue Specificity

Highly expressed in testis, where it is localized in germ cells, in particular in spermatocytes and in the pre-acrosome of round spermatids. Detected in the acrosome of ejaculated spermatozoa. Detected in adult thymus, bone marrow, colon, small intestine, appendix and placenta, and in fetal liver and thymus.

Subcellular Localizations

Nucleus. Chromosome, centromere, kinetochore. Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle.

Diseases

Microcephaly 4, primary, autosomal recessive (MCPH4)

Interacting Proteins

BUB1
BUB1B
PPP1CA

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KNL1

References

PMID: 10980622 by Hayette S., et al. AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14).

PMID: 12087463 by Takimoto M., et al. Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancer of smokers.