KMT2E Antibodies

AND KMT2E ELISA kits, KMT2E Proteins

Many biological assays use antibodies to detect KMT2E, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KMT2E in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KMT2E antibodies...

We validate the specificity of these antibodies to KMT2E by testing them on tissues known to express KMT2E positively and negatively. Browse below to find the KMT2E antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KMT2E Infographic by Boster Bio

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Anti-MLL5 KMT2E Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A08526
100ul

KMT2E Overview

Facts about Inactive histone-lysine N-methyltransferase 2E.

KMT2E 3D structure. Source: alphafold

Inactive histone-lysine N-methyltransferase 2E (KMT2E)

Associates with chromatin regions downstream of transcriptional start sites of genes that are active and so regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 in'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402).

Key regulator of hematopoiesis involved with terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism which involves DNA methylation (By similarity). Also functions as an important cell cycle regulator, engaging in cell cycle regulatory system machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655).

Gene Information

Human
Gene Name:	KMT2E
Uniprot:	Q8IZD2
Entrez:	55904

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

Inactive histone-lysine N-methyltransferase 2E

Molecular Weight

Mass (kDA):
204.965 kDA

Genomic Context


Human

Location:	7q22.3
Sequence:	7; NC_000007.14 (104940949..105115019)

Tissue Specificity

Widely expressed in both adult and fetal tissues (PubMed:12101424, PubMed:23958951). Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum (PubMed:12101424, PubMed:23958951). Isoform NKp44L: Not detected on circulating cells from healthy individuals, but is expressed on a large panel of tumor and transformed cells (PubMed:23958951).

Subcellular Localizations

Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Absent from the nucleolus (PubMed:14718661). Localizes to chromosome during interphase and to centrosomes during mitosis (PubMed:23798402). Dissociation from mitotic chromosome is likely due to histone H3 phosphorylation on 'Thr-3' and 'Thr-6' (PubMed:23798402).; [Isoform 3]: Nucleus, nucleoplasm. Nucleus speckle. Absent from the nucleolus (PubMed:23629655). Localizes to chromosome during interphase and to nucleus speckle during mitosis (PubMed:23798402). Dissociation from mitotic chromosome is lik

Interacting Proteins

NCR2
TP53

PTMs

Glycoprotein

Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KMT2E

References

PMID: 12101424 by Emerling B.M., et al. MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia.

PMID: 23958951 by Baychelier F., et al. Identification of a cellular ligand for the natural cytotoxicity receptor NKp44.