Kelch-like protein 15 Antibodies

AND KLHL15 ELISA kits, Kelch-like protein 15 Proteins

Many biological assays use antibodies to detect Kelch-like protein 15, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kelch-like protein 15 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kelch-like protein 15 antibodies...

We validate the specificity of these antibodies to Kelch-like protein 15 by testing them on tissues known to express KLHL15 positively and negatively. Browse below to find the KLHL15 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KLHL15 Infographic by Boster Bio

All KLHL15 Products

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Anti-Kelch-like protein 15 KLHL15 Antibody

Human, Mouse, Rat

ELISA, IF, ICC, WB

$449
Cat # A13892
0.1 mg

KLHL15 (NM_030624) Human Over-expression Lysate

Human

$960
Cat # LS080311
100 µg

KLHL15 Overview

Facts about Kelch-like protein 15.

KLHL15 3D structure. Source: alphafold

Kelch-like protein 15 (KLHL15)

Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:14528312). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275).

Acts as an adapter for CUL3 to target the DNA- end resection variable RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays an integral role in DNA damage response, favoring DNA double-strand repair through error-prone non- homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354).

Gene Information

Human
Gene Name:	KLHL15
Uniprot:	Q96M94
Entrez:	80311

Family

Belongs to:

No superfamily

Alternative Names

kelch-like 15 (Drosophila); kelch-like protein 15; KIAA1677; MGC126148; MGC126149

Molecular Weight

Mass (kDA):
69.775 kDA

Genomic Context


Human

Location:	Xp22.11
Sequence:	X; NC_000023.11 (23983720..24027186, complement)

Subcellular Localizations

Nucleus.

Diseases

Carcinogenesis

Pathways

Cytoskeleton Organization

PTMs

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KLHL15

References

PMID: 27561354 by Ferretti L.P., et al. Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection.

PMID: 14528312 by Furukawa M., et al. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.