Beta-klotho Antibodies

Beta-klotho (Klb)

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase.

Increases the ability of FGFR1 and FGFR4 to bind FGF21. .

Gene Information

Mouse
Gene Name:	Klb
Uniprot:	Q99N32
Entrez:	83379

Family

Belongs to:
glycosyl hydrolase 1 family

Alternative Names

betaKlotho; beta-klotho; BKL; KLB; klotho beta like; Klotho beta; klotho beta-like protein; MGC142213

Molecular Weight

Mass (kDA):
120.189 kDA

Genomic Context

Mouse
Location:	5|5 C3.1
Sequence:	5;

Tissue Specificity

Present in liver, muscle and white adipose tissue, but not in kidney (at protein level). Expressed in liver and pancreas, and at lower levels in skin, stomach, skeletal muscle, small intestine and lung.

Diseases

• Obesity
• Irritable Bowel Syndrome
• Insulin Resistance
• Neoplasms
• Diarrhea
• Irritable Bowel Syndrome With Diarrhea
• Cholecystolithiasis
• Malabsorption Syndrome
• Cholangiocarcinoma
• Carcinoma
• Malignant Neoplasms
• Liver Carcinoma
• Insulin Sensitivity

• Inflammation
• Stasis
• Dyslipidemias
• Infarction
• Malignant Tumor Of Colon
• Premature Aging Syndrome
• Constipation

Pathways

• Cell Proliferation
• Glucose Homeostasis
• Gallstone Formation
• Energy Homeostasis
• Regulation Of Glucose Homeostasis
• Excretion
• Cellular Homeostasis
• Entner-doudoroff Pathway
• Aging
• Hepatocyte Proliferation
• Chondrocyte Proliferation

• Senescence
• Drug Resistance
• Translation
• Cell Death
• Pathogenesis
• Secretion

PTMs

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Klb

Boster Bio - Best Uses Of The KLB Marker

KLB antibody research requires the use of high-affinity prima antibodies. This is because it is difficult to detect this molecule from a variety of samples. Boster Bio provides primary antibodies that are highly specific and have been validated for use in Western Blotting, Immunohistochemistry, and ELISA. High-affinity antibodies are crucial tools in research but their use is limited.

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Primary antibodies of high-affinity

Boster offers high-affinity prima antibodies for flow cytometry. This is essential in many scientific disciplines. These antibodies can be monoclonal, polyclonal, and have been extensively cited over the past 25 years. This high-affinity product line is ideal if researchers want to detect a biomarker with the highest sensitivity. There are many Boster ELISA kit options available. All are available on the company's tebu bio website.

ELISA kit are useful for detecting specific analytes even in crude preparations. These high-affinity antibody can be washed away using nonspecific bound substances, making them a useful tool to measure specific analytes. Boster Bio provides high affinity primary antibodies which are excellent for ELISA. ELISA kits are customizable to meet specific specifications and needs.

The use of single B cells allows for the isolation of high-affinity antibodies against target antigens in weeks, compared to months or years in the past. The method involves the isolation of viable cells from convalescent patients or immunized animals. To evaluate candidate antibodies, single cell sorting is also performed. This includes the recovery of paired VH/VL antigen genes. They provide high-affinity antibodies to clinical trials and researchers with them.

Boster Bio makes high-affinity primary antibody using the immune system of animals. ELISA kits are based on the ability of these antibodies to bind antigens. Examples of these immunoassays include Western Blotting, immunohistochemistry, histopathology tests, and ELISA, or enzyme-linked immunosorbent assay. Flow cytometry uses a flow cytometer to measure the number of certain cell types.

SLE can be diagnosed with neutralizing antibodies. These antibodies can be identified using flow cytometry. They are useful in confirming the diagnosis with a 96.7 percent specificity. To avoid misdiagnosis or delays in treatment, you need to closely follow-up. The La/SSB cDNA made it possible to accomplish this.

KLB Marker

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