KDM6B Antibodies

AND KDM6B ELISA kits, KDM6B Proteins

Many biological assays use antibodies to detect KDM6B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KDM6B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KDM6B antibodies...

We validate the specificity of these antibodies to KDM6B by testing them on tissues known to express KDM6B positively and negatively. Browse below to find the KDM6B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KDM6B Infographic by Boster Bio

All KDM6B Products

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Product

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Specificity

Applications

Price

Anti-KDM6B/JMJD3 Picoband® Antibody

Human, Mouse

ELISA, Flow Cytometry, WB

$370
Cat # A01309-1
100 μg/vial

Anti-JMJD3 KDM6B Antibody

Human, Mouse, Rat

ELISA, IF, ICC, WB

$449
Cat # A01309
0.1 mg

KDM6B Overview

Facts about Lysine-specific demethylase 6B.

KDM6B 3D structure. Source: alphafold

Lysine-specific demethylase 6B (KDM6B)

Histone demethylase that especially demethylates'Lys- 27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914).

Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory reaction by engaging in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402).

Gene Information

Human
Gene Name:	KDM6B
Uniprot:	O15054
Entrez:	23135

Family

Belongs to:

UTX family

Alternative Names

EC 1.14.11; EC 1.14.11.-; JmjC domain-containing protein 3; JMJD3; JMJD3lysine-specific demethylase 6B; jumonji domain containing 3, histone lysine demethylase; Jumonji domain-containing protein 3; KDM6B; KIAA0346jumonji domain containing 3; Lysine (K)specific Demethylase 6B; Lysine (K)-specific Demethylase 6B; Lysine demethylase 6B

Molecular Weight

Mass (kDA):
176.632 kDA

Genomic Context


Human

Location:	17p13.1
Sequence:	17; NC_000017.11 (7834210..7854796)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Inflammation
Retinoblastoma
Leukemia
Lymphoma
Prostatic Neoplasms
Teratoma
Infective Disorder
Malignant Neoplasm Of Prostate
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Carcinoma

Acute Promyelocytic Leukemia
Colonic Neoplasms
Inflammatory Response
Congenital Heart Defects
Radiation Injury
Autoimmunity
Malignant Tumor Of Colon

Interacting Proteins

ESR1

Pathways

Methylation
Demethylation
Gene Silencing
Neurogenesis
Senescence
Cell Differentiation
Histone Methylation
Histone Modification
Cellular Senescence
Histone Acetylation
Pathogenesis
Cell Death
Neural Tube Closure

Tissue Development
Chromatin Remodeling
Cell Proliferation
Dna Methylation
Tube Closure
Aging
Stem Cell Maintenance

PTMs

Methylation
Demethylation
Reduction

Acetylation
Phosphorylation
Deacetylation

Ubiquitination

Research Areas

Cancer
Chromatin Research
Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KDM6B

References

PMID: 17193924 by Hu L.Y., et al. An efficient strategy to identify early TPA-responsive genes during differentiation of HL-60 cells.

PMID: 17825402 by De Santa F., et al. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.