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- Table of Contents
Facts about Lysine-specific demethylase 5A.
Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors.
Human | |
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Gene Name: | KDM5A |
Uniprot: | P29375 |
Entrez: | 5927 |
Belongs to: |
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JARID1 histone demethylase family |
EC 1.14.11; EC 1.14.11.-; Histone demethylase JARID1A; JARID1AJumonji, AT rich interactive domain 1A (RBP2-like); Jumonji, AT rich interactive domain 1A (RBBP2-like); Jumonji/ARID domain-containing protein 1A; KDM5A; lysine (K)-specific demethylase 5A; RBBP-2; RBBP2lysine-specific demethylase 5A; RBP2retinoblastoma binding protein 2; Retinoblastoma-binding protein 2jumonji, AT rich interactive domain 1A
Mass (kDA):
192.095 kDA
Human | |
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Location: | 12p13.33 |
Sequence: | 12; NC_000012.12 (280057..389320, complement) |
Nucleus, nucleolus. Nucleus. Occupies promoters of genes involved in RNA metabolism and mitochondrial function.
PMID: 8414517 by Fattaey A.R., et al. Characterization of the retinoblastoma binding proteins RBP1 and RBP2.
PMID: 1857421 by Defeo-Jones D., et al. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product.