KDM4C Antibodies

AND KDM4C ELISA kits, KDM4C Proteins

Many biological assays use antibodies to detect KDM4C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KDM4C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KDM4C antibodies...

We validate the specificity of these antibodies to KDM4C by testing them on tissues known to express KDM4C positively and negatively. Browse below to find the KDM4C antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KDM4C Infographic by Boster Bio

All KDM4C Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

KDM4C (NM_015061) Human Recombinant Protein

$1062
Cat # PROTQ9H3R0
20 µg

Anti-KDM4C Mouse Monoclonal Antibody [Clone ID: OTI5B9]

+10

Human, Rat

IF, IHC, WB

$523
Cat # M04689
100 µl

Anti-KDM4C Mouse Monoclonal Antibody [Clone ID: OTI4B1]

Human, Rat

Flow Cytometry, IF, IHC

$523
Cat # M04689-1
100 µl

Anti-JMJD2C Antibody (C-term)

Human, Mouse

Flow Cytometry, WB

$299
Cat # A04689
80 µl

KDM4C (NM_015061) Human Over-expression Lysate

Human

$628
Cat # LS023081
100 µg

KDM4C Overview

Facts about Lysine-specific demethylase 4C.

KDM4C 3D structure. Source: alphafold

Lysine-specific demethylase 4C (KDM4C)

Histone demethylase that specifically demethylates'Lys- 9' and'Lys-36' residues of histone H3, thereby playing a fundamental role in histone code. Does not demethylate histone H3'Lys-4', H3'Lys-27' nor H4'Lys-20'.

Demethylates trimethylated H3'Lys-9' and H3'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue creates formaldehyde and succinate.

Gene Information

Human
Gene Name:	KDM4C
Uniprot:	Q9H3R0
Entrez:	23081

Family

Belongs to:

JHDM3 histone demethylase family

Alternative Names

EC 1.14.11; EC 1.14.11.-; GASC-1 protein; GASC1; GASC1JmjC domain-containing histone demethylation protein 3C; Gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JMJD2C; JMJD2CbA146B14.1; jumonji domain containing 2C; Jumonji domain-containing protein 2C; KDM4C; KIAA0780FLJ25949; Lysine (K)specific Demethylase 4C; Lysine (K)-specific Demethylase 4C; lysine-specific demethylase 4C

Molecular Weight

Mass (kDA):
119.982 kDA

Genomic Context


Human

Location:	9p24.1
Sequence:	9; NC_000009.12 (6720863..7175648)

Tissue Specificity

Overexpressed in several esophageal squamous cell carcinomas (ESCs).

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Carcinoma
Neoplasms
Malignant Squamous Cell Neoplasm
Cell Transformation, Neoplastic
Leukemia
Malignant Neoplasm Of Breast
Esophageal Neoplasms
Prostatic Neoplasms
Leukemia, Myelocytic, Acute
Neoplasm Metastasis
Myeloid Leukemia
Mammary Neoplasms

Lymphoma
Malignant Neoplasm Of Prostate
Autistic Disorder
Hyperplasia
Infectious Mononucleosis
Glioma
Hypoxia

Pathways

Methylation
Demethylation
Pathogenesis
Dna Methylation
Histone Methylation
Cell Proliferation
Histone Demethylation
Histone Modification
Cell Differentiation
Gene Silencing
Response To Hypoxia

Histone Phosphorylation
Histone H3 Acetylation
Dna Amplification
Histone Acetylation
Rna Interference
Chromatin Remodeling

PTMs

Methylation
Demethylation

Phosphorylation
Reduction

Acetylation

Research Areas

Epigenetics

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KDM4C

References

PMID: 10987278 by Yang Z.Q., et al. Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.

PMID: 16603238 by Whetstine J.R., et al. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.