Lysine-specific demethylase 3A (KDM3A)

Histone demethylase that especially demethylates'Lys- 9' of histone H3, thereby playing a fundamental role in histone code. Preferentially demethylates mono- and dimethylated H3'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3'Lys-9'.

Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by engaging in recruitment to androgen-receptor target genes, resulting in H3'Lys-9' demethylation and transcriptional activation.