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- Table of Contents
Facts about Lysine-specific demethylase 3A.
Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by engaging in recruitment to androgen-receptor target genes, resulting in H3'Lys-9' demethylation and transcriptional activation.
Human | |
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Gene Name: | KDM3A |
Uniprot: | Q9Y4C1 |
Entrez: | 55818 |
Belongs to: |
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JHDM2 histone demethylase family |
EC 1.14.11; EC 1.14.11.-; JHDM2A; JHDM2AJMJD1AJHMD2A; JmjC domain-containing histone demethylation protein 2A; JMJD1; JMJD1A; jumonji C domain-containing histone demethylase 2A; jumonji domain containing 1; jumonji domain containing 1A; Jumonji domain-containing protein 1A; KDM3A; KIAA0742; KIAA0742DKFZp686A24246; Lysine (K)specific Demethylase 3A; Lysine (K)-specific Demethylase 3A; lysine-specific demethylase 3A; testis-specific protein A; TSGA; TSGADKFZp686P07111
Mass (kDA):
147.341 kDA
Human | |
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Location: | 2p11.2 |
Sequence: | 2; NC_000002.12 (86440647..86492716) |
Cytoplasm. Nucleus. Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity).
PMID: 16603237 by Yamane K., et al. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.
PMID: 28262558 by Tumber A., et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.