KCNJ8 Antibodies

AND KCNJ8 ELISA kits, KCNJ8 Proteins

Many biological assays use antibodies to detect KCNJ8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNJ8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNJ8 antibodies...

We validate the specificity of these antibodies to KCNJ8 by testing them on tissues known to express KCNJ8 positively and negatively. Browse below to find the KCNJ8 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNJ8 Infographic by Boster Bio

All KCNJ8 Products

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Product

Figures

Specificity

Applications

Price

Anti-IRK8 KCNJ8 Antibody

Human

ELISA, WB

$380
Cat # A04950
100ul

Anti-Kir6.1/KCNJ8 Antibody Picoband®

1 Citations

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A04950-1
100 μg/vial

KCNJ8 (NM_004982) Human Over-expression Lysate

Human

$628
Cat # LS003764
100 µg

KCNJ8 Overview

Facts about ATP-sensitive inward rectifier potassium channel 8.

KCNJ8 3D structure. Source: alphafold

ATP-sensitive inward rectifier potassium channel 8 (KCNJ8)

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.

Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Gene Information

Human
Gene Name:	KCNJ8
Uniprot:	Q15842
Entrez:	3764

Family

Belongs to:

inward rectifier-type potassium channel (TC 1.A.2.1) family

Alternative Names

ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; inwardly rectifying potassium channel KIR6.1; Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; potassium inwardly-rectifying channel, subfamily J, member 8; uKATP-1

Molecular Weight

Mass (kDA):
47.968 kDA

Genomic Context


Human

Location:	12p12.1
Sequence:	12; NC_000012.12 (21764955..21775593, complement)

Tissue Specificity

Predominantly detected in fetal and adult heart.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Cardiac Arrhythmia
Diabetes Mellitus
Brugada Syndrome (disorder)
Cardiac Fibrillation
Sudden Death
Ventricular Fibrillation
Ischemia
Malnutrition
Neoplasms
Sudden Cardiac Death
Pathologic Vasoconstriction
Channelopathies
Angina Pectoris

Diabetes Mellitus, Non-insulin-dependent
Heart Diseases
Angina Pectoris, Variant
Cardiac Death
Infarction
Myocardial Infarction
Systemic Infection

Pathways

Pathogenesis
Transport
Vasodilation
Rna Interference
Secretion
Ion Transport
Hypersensitivity
Protein Secretion
Localization
Inflammatory Response

Neuroprotection
Sensitization
Ureter Development
Vasoconstriction

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNJ8

References

PMID: 8595887 by Inagaki N., et al. cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8).

PMID: 9573340 by Erginel-Unaltuna N., et al. Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel.

1 Publications of Boster KCNJ8 Antibodies & ELISA Kits

PubMed ID: 10.1016/S0254-6272(12)60012-0, Astragaloside IV Regulates Expression of ATP-sensitive Potassium Channel Subunit...

*More publications can be found for each product on its corresponding product page