KCNIP4 Antibodies

AND KCNIP4 ELISA kits, KCNIP4 Proteins

Many biological assays use antibodies to detect KCNIP4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNIP4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNIP4 antibodies...

We validate the specificity of these antibodies to KCNIP4 by testing them on tissues known to express KCNIP4 positively and negatively. Browse below to find the KCNIP4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNIP4 Infographic by Boster Bio

All KCNIP4 Products

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Product

Figures

Specificity

Applications

Price

KCNIP4 (NM_001035004) Human Recombinant Protein

$813
Cat # PROTQ6PIL6
20 µg

KCNIP4 (NM_025221) Human Over-expression Lysate

Human

$628
Cat # LS080333
100 µg

KCNIP4 Overview

Facts about Kv channel-interacting protein 4.

KCNIP4 3D structure. Source: alphafold

Kv channel-interacting protein 4 (KCNIP4)

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation at a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435).

Modulates KCND3/Kv4.3 currents (PubMed:23576435).

Gene Information

Human
Gene Name:	KCNIP4
Uniprot:	Q6PIL6
Entrez:	80333

Family

Belongs to:

recoverin family

Alternative Names

A-type potassium channel modulatory protein 4; Calsenilin-like protein; KChIP4; KCHIP4CALPMGC44947; Kv channel interacting protein 4; Kv channel-interacting protein 4; potassium channel interacting protein 4; Potassium channel-interacting protein 4

Molecular Weight

Mass (kDA):
28.729 kDA

Genomic Context


Human

Location:	4p15.31-p15.2
Sequence:	4; NC_000004.12 (20728520..21948772, complement)

Tissue Specificity

Predominantly expressed in brain.

Subcellular Localizations

Cell membrane; Peripheral membrane protein. Cytoplasm.; [Isoform 4]: Endoplasmic reticulum.

Diseases

Malignant Neoplasms
Alzheimer's Disease
Sclerosis
Primary Lateral Sclerosis
Drug-induced Liver Injury
Malignant Neoplasm Of Breast
Dementia
Kidney Neoplasm
Amyotrophic Lateral Sclerosis
Parkinson Disease
Fibrosarcoma
Nervousness
Renal Cell Carcinoma

5,10-methylenetetrahydrofolate Reductase Deficiency
Chromosome Breakage
Lymphoma
Cytogenetic Abnormality
L1 Acute Lymphoblastic Leukemia
Hepatotoxicity
Frontotemporal Dementia

Interacting Proteins

COL1A2

Pathways

Pathogenesis
Neuron Death
Localization
Secretion
Protein Processing

PTMs

Phosphorylation

Cleavage

Gamma-cleavage

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNIP4

References

PMID: 11847232 by Morohashi Y., et al. Molecular cloning and characterization of CALP/KChIP4, a novel EF- hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.

PMID: 11805342 by Holmqvist M.H., et al. Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain.