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- Table of Contents
Facts about Potassium voltage-gated channel subfamily D member 3.
Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. .
Human | |
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Gene Name: | KCND3 |
Uniprot: | Q9UK17 |
Entrez: | 3752 |
Belongs to: |
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potassium channel family |
KCND3L; KCND3S; KSHIVB; Kv4.3; MGC142035; MGC142037; potassium ionic channel Kv4.3; potassium voltage-gated channel subfamily D member 3; potassium voltage-gated channel, Shal-related subfamily, member 3; sha1-related potassium channel Kv4.3; voltage-gated K+ channel; voltage-gated potassium channel Kv4.3; Voltage-gated potassium channel subunit Kv4.3
Mass (kDA):
73.451 kDA
Human | |
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Location: | 1p13.2 |
Sequence: | 1; NC_000001.11 (111770662..111989577, complement) |
Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas.
Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection, dendrite. Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression.
PMID: 9843794 by Kong W., et al. Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.
PMID: 10200233 by Dilks D., et al. Cloning and expression of the human Kv4.3 potassium channel.