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KCNE1 Antibodies
AND KCNE1 ELISA kits, KCNE1 Proteins
Many biological assays use antibodies to detect KCNE1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNE1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNE1 antibodies...
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KCNE1 Overview
Facts about Potassium voltage-gated channel subfamily E member 1.
Potassium voltage-gated channel subfamily E member 1 (KCNE1)
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the station complex.
Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is suggested to form the slowly activating delayed rectifier cardiac potassium (IKs) channel.
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNE1 |
| Uniprot: | P15382 |
| Entrez: | 3753 |
Family
| Belongs to: |
|---|
| potassium channel KCNE family |
Alternative Names
Delayed rectifier potassium channel subunit IsK; FLJ18426; FLJ38123; IKs producing slow voltage-gated potassium channel subunit beta Mink; ISK; Isk-related subfamily, member 1; JLNS2FLJ94103; LQT2/5; MGC33114; Minimal potassium channel; MinK; potassium voltage-gated channel, Isk-related family, member 1; voltage gated potassiun channel accessory subunit
Molecular Weight
Mass (kDA):
14.675 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.12 |
| Sequence: | 21; NC_000021.9 (34446688..34512210, complement) |
Tissue Specificity
Expressed in lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Expressed in the heart (PubMed:19219384). Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Apical cell membrane. Membrane raft. Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KCNQ1 (PubMed:20533308).
Diseases
- Long Qt Syndrome
- Cardiac Arrhythmia
- Sudden Death
- Syncope
- Sudden Cardiac Death
- Cardiac Fibrillation
- Complete Hearing Loss
- Jervell-lange Nielsen Syndrome
- Long Qt Syndrome Congenital
- Torsades De Pointes
- Atrial Fibrillation
- Cardiac Death
- Tachycardia, Ventricular
Interacting Proteins
- KCNQ1
Pathways
- Secretion
- Transport
- Localization
- Pathogenesis
- Acid Secretion
- Gastric Acid Secretion
- Cell Proliferation
- Excretion
- Secretory Pathway
- Cardiac Conduction
- Membrane Depolarization
- Glycosylation
- Coagulation
PTMs
- Phosphorylation
- Biotinylation
- Reduction
- Glycosylation
- Hydroxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNE1
bosterbio.com/bosterbio-gene-info-cards/KCNE1
References
PMID: 2730656 by Murai T., et al. Molecular cloning and sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity.
PMID: 7828904 by Lai L.P., et al. Polymorphism of the gene encoding a human minimal potassium ion channel (minK).