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- Table of Contents
Facts about Potassium voltage-gated channel subfamily D member 2.
This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials in the neuronal cell body to the dendrites.
Human | |
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Gene Name: | KCND2 |
Uniprot: | Q9NZV8 |
Entrez: | 3751 |
Belongs to: |
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potassium channel family |
potassium voltage-gated channel, Shal-related subfamily, member 2; RK5; voltage-gated potassium channel Kv4.2; voltage-sensitive potassium channel
Mass (kDA):
70.537 kDA
Human | |
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Location: | 7q31.31 |
Sequence: | 7; NC_000007.14 (120273175..120750337) |
Detected in ovary, in corpus luteum and in granulosa and theca cells in the follicle (at protein level) (PubMed:15991246). Highly expressed throughout the brain (PubMed:10551270, PubMed:10729221). Detected in amygdala, caudate nucleus, cerebellum, hippocampus, substantia nigra and thalamus (PubMed:10551270, PubMed:10729221). Expression is not detectable or very low in heart, kidney, liver, lung, pancreas and skeletal muscle (PubMed:10551270, PubMed:10729221). Not detectable in human heart atrium (PubMed:12395204).
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell junction, synapse. Perikaryon. Cell junction, synapse, postsynaptic cell membrane. Cell projection, dendritic spine. Cell junction. In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons. Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer. Detected at GABAergic synapses. Detected at cell junctions that are distinct from synaptic cell contacts. Detected in lipid rafts. Detected primarily at the endoplasmic reticulum or Golgi when
PMID: 9843794 by Kong W., et al. Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.
PMID: 10551270 by Zhu X.-R., et al. Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current.