KATNAL1 Antibodies

AND KATNAL1 ELISA kits, KATNAL1 Proteins

Many biological assays use antibodies to detect KATNAL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KATNAL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KATNAL1 antibodies...

We validate the specificity of these antibodies to KATNAL1 by testing them on tissues known to express KATNAL1 positively and negatively. Browse below to find the KATNAL1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KATNAL1 Infographic by Boster Bio

All KATNAL1 Products

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Product

Figures

Specificity

Applications

Price

Anti-KATNAL1 Mouse Monoclonal Antibody [Clone ID: OTI1A7]

Human, Monkey, Mouse, Rat

Flow Cytometry, IHC, WB

$523
Cat # M11734
100 µl

KATNAL1 (NM_032116) Human Over-expression Lysate

Human

$628
Cat # LS084056
100 µg

KATNAL1 Overview

Facts about Katanin p60 ATPase-containing subunit A-like 1.

KATNAL1 3D structure. Source: alphafold

Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1)

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent fashion, promoting rapid reorganization of cellular microtubule arrays (By similarity).

Has microtubule-severing activity in vitro (PubMed:26929214). .

Gene Information

Human
Gene Name:	KATNAL1
Uniprot:	Q9BW62
Entrez:	84056

Family

Belongs to:

AAA ATPase family

Alternative Names

EC 3.6.4.3; katanin p60 ATPase-containing subunit A-like 1; katanin p60 subunit A-like 1MGC2599; p60 katanin-like 1

Molecular Weight

Mass (kDA):
55.392 kDA

Genomic Context


Human

Location:	13q12.3
Sequence:	13; NC_000013.11 (30200026..30307551, complement)

Tissue Specificity

Expressed in testis, restricted to Sertoli cells (at protein level).

Subcellular Localizations

Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214).

Diseases

Male Infertility
Infertility

Interacting Proteins

C1orf109
CEP57L1
COX17
KATNB1
KATNBL1

KLC4
SIAH1
ZNF69

Pathways

Transport
Microtubule Severing
Spermatogenesis

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KATNAL1

References

PMID: 22654668 by Smith L.B., et al. KATNAL1 regulation of Sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility.

PMID: 26929214 by Cheung K., et al. Proteomic analysis of the mammalian Katanin family of microtubule- severing enzymes defines Katanin p80 subunit B-like 1 (KATNBL1) as a regulator of mammalian Katanin microtubule-severing.