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- Table of Contents
Facts about Junction-mediating and -regulatory protein.
Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response like DNA damage. In cytoplasm, functions as a nucleation-promoting factor for both branched and unbranched actin filaments.
Mouse | |
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Gene Name: | Jmy |
Uniprot: | Q9QXM1 |
Entrez: | 57748 |
Belongs to: |
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JMY family |
FLJ37870; junction mediating and regulatory protein, p53 cofactor; junction-mediating and regulatory protein; junction-mediating and -regulatory protein; MGC163496; WAS protein homology region 2 domain containing 1-like 3; WHDC1L3
Mass (kDA):
110.586 kDA
Mouse | |
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Location: | 13|13 C3 |
Sequence: | 13; |
Widely expressed, except in testis where it is expressed at low level.
PMID: 10518217 by Shikama N., et al. A novel cofactor for p300 that regulates the p53 response.
PMID: 11511361 by Demonacos C., et al. A TPR motif cofactor contributes to p300 activity in the p53 response.