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JAM3 Antibodies
AND JAM3 ELISA kits, JAM3 Proteins
Many biological assays use antibodies to detect JAM3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with JAM3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop JAM3 antibodies...
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JAM3 Infographic by Boster Bio
All JAM3 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$499
Cat # EK1840
96 wells/kit, with removable strips.
Cat # EK1840
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # EK1844
96 wells/kit, with removable strips.
Cat # EK1844
96 wells/kit, with removable strips.
Human
$628
Cat # LS083700
100 µg
Cat # LS083700
100 µg
JAM3 Overview
Facts about Junctional adhesion molecule C.
Junctional adhesion molecule C (JAM3)
Mediates cell-cell adhesion (PubMed:11590146, PubMed:12208882, PubMed:15194813). Functions as counter-receptor for JAM2 (PubMed:11590146).
Functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084).
Gene Information
| Human | |
|---|---|
| Gene Name: | JAM3 |
| Uniprot: | Q9BX67 |
| Entrez: | 83700 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
CD323; JAM-2; JAM3; JAMC; JAM-C; JAM-CFLJ14529; junctional adhesion molecule 3JAM-3; junctional adhesion molecule C
Molecular Weight
Mass (kDA):
35.02 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q25 |
| Sequence: | 11; NC_000011.10 (134068925..134152001) |
Tissue Specificity
Detected on round and elongated spermatids (at protein level) (PubMed:15372036). Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level).
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, desmosome. Cell junction, tight junction. Detected in the acrosome region in developing spermatids (By similarity). In epithelial cells, it is expressed at desmosomes but not at tight junctions (PubMed:15194813). Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (PubMed:15994945).; [Soluble form of JAM-C]: Secreted.
Diseases
- Tissue Adhesions
- Inflammation
- Neoplasms
- Malignant Neoplasms
- Neoplasm Metastasis
- Extravasation
- Melanoma
- Tumor Angiogenesis
- Arthritis
- Reperfusion Injury
- Congenital Heart Defects
- Cytogenetic Abnormality
- Jacobsen Distal 11q Deletion Syndrome
Interacting Proteins
- JAM2
Pathways
- Localization
- Cell Adhesion
- Cell Migration
- Immune Response
- Leukocyte Migration
- Spermatogenesis
- Angiogenesis
- Diapedesis
- Chemokine Production
- Platelet Activation
- Hypersensitivity
- Establishment Of Cell Polarity
- Dna Methylation
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JAM3
bosterbio.com/bosterbio-gene-info-cards/JAM3
References
PMID: 11590146 by Arrate M.P., et al. Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor.
PMID: 11739175 by Aurrand-Lions M.A., et al. Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members.