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Apelin receptor Antibodies
AND APLNR ELISA kits, Apelin receptor Proteins
Many biological assays use antibodies to detect Apelin receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Apelin receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Apelin receptor antibodies...
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APLNR Overview
Facts about Apelin receptor.
Apelin receptor (APLNR)
Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a vital role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity).
May promote angioblast migration toward the embryonic midline, i.e.
Gene Information
| Human | |
|---|---|
| Gene Name: | APLNR |
| Uniprot: | P35414 |
| Entrez: | 187 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
AGTRL1; AGTRL1HG11; angiotensin II receptor-like 1; Angiotensin receptor-like 1; apelin receptor; APJ (apelin) receptor; APJ receptor; APJ; APJFLJ96609; APJR; APLNR; FLJ90771; G protein-coupled receptor APJ; G-protein coupled receptor APJ; G-protein coupled receptor HG11; HG11 orphan receptor; HG11; MGC45246
Molecular Weight
Mass (kDA):
42.66 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.1 |
| Sequence: | 11; NC_000011.10 (57233577..57237453, complement) |
Tissue Specificity
Expressed in heart, brain, kidney, stomach, spleen, thymus, lung, ovary, small intestine and colon, adipose tissues and pancreas (PubMed:8294032, PubMed:25639753). Expressed in glial cells, astrocytes and neuronal subpopulations (PubMed:8294032). Expressed in embryonic (ESCs) and induced (iPSCs) pluripotent stem cells (PubMed:25639753).
Subcellular Localizations
Cell membrane. After exposure to apelin (APLN), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (By similarity). After exposure to apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:25639753).
Diseases
- Tumor Angiogenesis
- Hiv Infections
- Immunologic Deficiency Syndromes
- Pathologic Neovascularization
- Hypertensive Disease
- Nervousness
- Heart Failure
- Hypoxia
- Cardiovascular Diseases
- Atherosclerosis
- Obesity
- Diabetes Mellitus
Interacting Proteins
- AGTR1
- OPRK1
Pathways
- Angiogenesis
- Localization
- Secretion
- Cell Proliferation
- Vasoconstriction
- Pathogenesis
- Regulation Of Blood Pressure
- Receptor Internalization
- Cellular Localization
- Heart Development
- Cell Migration
- Tropism
- Glucose Homeostasis
PTMs
- Phosphorylation
- Nitration
- Reduction
Research Areas
- GPCR
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APLNR
bosterbio.com/bosterbio-gene-info-cards/APLNR
References
PMID: 8294032 by O'Dowd B.F., et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11.
PMID: 11090199 by Cayabyab M., et al. Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry.