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- Table of Contents
Facts about Protein Jade-1.
Promotes apoptosis. May act as a renal tumor suppressor.
Human | |
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Gene Name: | JADE1 |
Uniprot: | Q6IE81 |
Entrez: | 79960 |
Belongs to: |
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JADE family |
Protein Jade-1
Mass (kDA):
95.533 kDA
Human | |
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Location: | 4q28.2 |
Sequence: | 4; NC_000004.12 (128809687..128875224) |
Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, cilium basal body. Localizes to the ciliary transition zone.
PMID: 12169691 by Zhou M.I., et al. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1.
PMID: 14612400 by Tzouanacou E., et al. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.