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Inner centromere protein Antibodies
AND INCENP ELISA kits, Inner centromere protein Proteins
Many biological assays use antibodies to detect Inner centromere protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Inner centromere protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Inner centromere protein antibodies...
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INCENP Overview
Facts about Inner centromere protein.
Inner centromere protein (INCENP)
Part of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring proper chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.
Acts as a scaffold regulating CPC localization and action. The C-terminus associates with AURKB or AURKC, the N-terminus connected with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895).
Gene Information
| Human | |
|---|---|
| Gene Name: | INCENP |
| Uniprot: | Q9NQS7 |
| Entrez: | 3619 |
Family
| Belongs to: |
|---|
| INCENP family |
Alternative Names
binds and activates aurora-B and -C in vivo and in vitro; chromosomal passenger protein; FLJ31633; inner centromere protein antigens (135kD, 155kD); inner centromere protein antigens 135/155kDa; inner centromere protein INCENP; inner centromere protein; MGC111393
Molecular Weight
Mass (kDA):
105.429 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.3 |
| Sequence: | 11; NC_000011.10 (62123998..62155474) |
Subcellular Localizations
Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome, centromere, kinetochore. Colocalized at synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocenters. Colocalizes with AURKB at a connecting strand traversing the centromere region and joining sister kinetochores, in metaphase II centromeres. This strand disappears at the metaphase II/anaphase II transition and relocalizes to the spindle midzone (By similarity). Colocalizes with AURKB at mitotic chromosomes (PubMed:11453556). Localizes
Diseases
- Malignant Neoplasms
- Neoplasms
- Aneuploidy
- Cell Transformation, Neoplastic
- Polyploidy
- Carcinoma
- Misalignment
- Colorectal Cancer
- Endoreduplication
- Genomic Instability
- Rheumatism
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- AURKA
- AURKB
- AURKC
- BIRC5
- CBX5
- CDCA8
Pathways
- Mitosis
- Cytokinesis
- Localization
- Chromosome Segregation
- Anaphase
- Metaphase
- Cell Division
- Spindle Assembly
- Cell Cycle
- Meiosis
- Spindle Assembly Checkpoint
- Spindle Checkpoint
- Chromosome Condensation
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
Research Areas
- Cell Cycle and Replication
- Chromatin Research
- DNA Repair
- Mitotic Regulators
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/INCENP
bosterbio.com/bosterbio-gene-info-cards/INCENP
References
PMID: 11453556 by Adams R.R., et al. Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells.
PMID: 15316025 by Li X., et al. Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.