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- Table of Contents
Facts about Inhibitor of growth protein 2.
ING2 activity appears to be modulated by binding to phosphoinositides (PtdInsPs). .
Human | |
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Gene Name: | ING2 |
Uniprot: | Q9H160 |
Entrez: | 3622 |
Belongs to: |
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ING family |
ING1Linhibitor of growth family, member 1-like; ING1Lp; Inhibitor of growth 1-like protein; inhibitor of growth family, member 2; inhibitor of growth protein 2; p33ING2p32
Mass (kDA):
32.808 kDA
Human | |
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Location: | 4q35.1 |
Sequence: | 4; NC_000004.12 (183505058..183512429) |
Widely expressed. Higher expressed in colon- cancer tumor than in normal colon tissues.
Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
PMID: 10072587 by Shimada Y., et al. Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor.
PMID: 11481424 by Nagashima M., et al. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.