This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Gamma-interferon-inducible lysosomal thiol reductase.
Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity).
Human | |
---|---|
Gene Name: | IFI30 |
Uniprot: | P13284 |
Entrez: | 10437 |
Belongs to: |
---|
GILT family |
EC 1.8; Gamma-interferon-inducible protein IP-30; GILT; GILTgamma-interferon-inducible lysosomal thiol reductase; IFI30; IFI-30; interferon, gamma-inducible protein 30; IP30; IP30interferon gamma-inducible protein 30 preproprotein; Legumaturain; MGC32056
Mass (kDA):
27.964 kDA
Human | |
---|---|
Location: | 19p13.11 |
Sequence: | 19; NC_000019.10 (18173813..18178117) |
Secreted. Lysosome.
If you're wondering what the Boster Bio Anti-GILT/IFI30 Antibody Picoband is all about, keep reading. You'll learn about the company's history, its Products, and best uses for the IFI30 marker. Plus, learn about the IFI30 Marker itself. And, find out how you can use this unique marker to improve your research and your work.
The Boster Bio Anti-GILT/IFi30 is an antibody available in the Picoband(tm) catalog. This product reacts with Human, Mouse, and Rat cells. It can be stored at -20°C for six months. Each vial contains trehalose. It is formulated for reagent-grade quality and is guaranteed to be effective for a given period of time.
The Picokine(tm) platform is designed to improve ELISA sensitivity to the picogram level. The Picokine(tm) ELISA kits are validated across a wide range of samples. The validation images and procedure are available on request. The Supervision secondary antibody is a polymer-based reagent that saves up to 30 minutes in immunohistochemistry (IHC). The Picoband is supported by insights in the design of immunogens and technical support from the BeNeLux distributor Sanbio.
ELISA is a standard testing method for measuring human antibodies. Several methods are available, including Boster Bio Anti-GILT/IFI30 Antibody Picoband. These antibodies have excellent sensitivity against human GILT/IFI30. In fact, these two antibodies have an 85% specificity rate, which means they are useful in the detection of many other diseases.
Boster Bio, a leading antibody manufacturer, has over 12,000 antibodies for ELISA and IHC tests. Boster Bio validates its antibodies for sensitivity and specificity against a panel of 250 tissues. In addition to qualitative testing, Boster Bio also performs quantitative validation by analyzing their results against recombinant proteins and cell lines. This results in high affinity for a wide range of target proteins.
In 1993, Steven Boster developed his first product, earning him the nickname "he who converts science in the lavatory." He developed products for IHC and thousands of primary antibodies. By the late 1990s, he had become the largest catalog antibody company in China. He also developed a proprietary ELISA platform called PicoKine(tm). This platform uses proprietary trade secrets to deliver high-sensitivity ELISA kits.
The products offered by Boster Bio include antibodies, ELISA kits, and control reagents. The company manufactures these reagents in-house and has over 20 years of experience. Their products are tested using real tissues and known amounts of recombinant proteins. They can also provide custom services and beNeLux deliveries. This comprehensive list of Boster Bio products enables researchers to design experiments for their research needs.
Immunohistochemistry is a special staining process that detects antigens and haptens in cell tissues. Boster Bio optimises antibody dilutions and cell and tissue dilution ratios to get the most accurate results. They also offer Multiplex Immunohistochemistry services, which can detect multiple targets simultaneously and provide fast assay processing. They accept smear slides and can even provide custom antibodies.
Boster Bio specializes in creating high-quality antibodies for research. Their ELISA kits, antibodies, and reagents are backed by over 29,000 citations and are optimized for use in ELISA and WB assays. The company also offers multiplex immunohistochemistry services, which can archive results in record time at a low cost. The company also offers several hundred and fifty IHC articles.
A recent study found that the IFI30 Marker is associated with poor outcome in gliomas. Increased levels of IFI30 expression correlated with increased immune scores in TCGA and CGGA data, and the gene was found to participate in the processing of MHC II-associated antigen. Immune cell type was evaluated using CIBERSORT. Here are some of the applications of the IFI30 Marker:
IFI30 expression in LGG cancer patients has been used to distinguish between IDH-mutant and non-codeleted 1p/19q tumours. IDH-mut patients had a worse outcome than IDH-wt patients. Moreover, the expression of IFI30 was associated with age and tumour grade. These results indicate that IFI30 expression could be used to distinguish between patients with LGG with diverse types.
In addition to tumours, IFI30 has been found to influence immune cell infiltration. In the study, samples with high IFI30 expression exhibited high levels of regulatory T cells (Tregs), M0 macrophages, and gamma delta T cells. Furthermore, IFI30 expression was positively correlated with immunosuppressive cytokines, a hallmark of the tumour microenvironment. This study furthermore adds to the body of knowledge on the immune response to glioma. It may even provide clues to novel therapeutic targets.
In addition to its prognostic value, IFI30 was also evaluated in GBM patients. IDh2 wild-type and mutant groups were associated with decreased IFI30 expression. This study further supports the notion that IFI30 expression may be related to the malignancy of GBM. If we find that the IFI30 protein can predict patient survival in GBM patients, we will know what to look for.
PMID: 3136170 by Luster A.D., et al. Molecular and biochemical characterization of a novel gamma- interferon-inducible protein.
PMID: 10639150 by Arunachalam B., et al. Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT).