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- Table of Contents
Facts about Nuclear nucleic acid-binding protein C1D.
Can trigger PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent way.
Human | |
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Gene Name: | C1D |
Uniprot: | Q13901 |
Entrez: | 10438 |
Belongs to: |
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C1D family |
C1D DNA-binding protein; C1D nuclear receptor corepressor; C1D nuclear receptor co-repressor; C1D; hC1D; MGC12261; MGC14659; nuclear DNA-binding protein; nuclear nucleic acid-binding protein C1D; small unique nuclear receptor corepressor; small unique nuclear receptor co-repressor; SUNCOR; SUN-CoR; SUNCORLRP1
Mass (kDA):
16.019 kDA
Human | |
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Location: | 2p14 |
Sequence: | 2; NC_000002.12 (68041130..68063004, complement) |
Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon.
Nucleus. Cytoplasm. Nucleus, nucleolus. EXOSC10 is required for nucleolar localization (PubMed:17412707). Colocalizes with TSNAX in the nucleus (PubMed:11801738).
PMID: 9469821 by Nehls P., et al. cDNA cloning, recombinant expression and characterization of polypeptides with exceptional DNA affinity.
PMID: 9679063 by Yavuzer U., et al. DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D.