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ITGB1BP1 Antibodies
AND ITGB1BP1 ELISA kits, ITGB1BP1 Proteins
Many biological assays use antibodies to detect ITGB1BP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ITGB1BP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ITGB1BP1 antibodies...
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ITGB1BP1 Infographic by Boster Bio
All ITGB1BP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M05778
100 µl
Cat # M05778
100 µl
ITGB1BP1 Overview
Facts about Integrin beta-1-binding protein 1.
Integrin beta-1-binding protein 1 (ITGB1BP1)
Key regulator of this integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis.
Stimulates cellular proliferation in a fibronectin- dependent way. Involved in the regulation of beta-1 integrin- containing focal adhesion (FA) site dynamics by controlling its assembly speed during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner.
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGB1BP1 |
| Uniprot: | O14713 |
| Entrez: | 9270 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Bodenin; DKFZp686K08158; ICAP1; ICAP-1; ICAP-1alpha; ICAP-1B; ICAP1ICAP1AICAP1BICAP-1A; integrin beta 1 binding protein 1; integrin beta-1-binding protein 1; Integrin cytoplasmic domain-associated protein 1; integrin cytoplasmic domain-associated protein 1-alpha; integrin cytoplasmic domain-associated protein 1-beta; ITGB1BP1
Molecular Weight
Mass (kDA):
21.782 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p25.1 |
| Sequence: | 2; NC_000002.12 (9403475..9423569, complement) |
Tissue Specificity
Expressed in endothelial cells and fibroblasts (at protein level). Ubiquitously expressed. Expressed in intestine, colon, testis, ovary, thymus, spleen and prostate.
Subcellular Localizations
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle. Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in a integrin-dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 i
Diseases
- Tissue Adhesions
- Cavernous Hemangioma Of Brain
- Neoplasm Metastasis
- Tumor Angiogenesis
- Malignant Neoplasms
- Neoplasms
- Nervousness
- Pathologic Neovascularization
- Cell Invasion
- Hemangioma, Cavernous, Central Nervous System
- Cholangiocarcinoma
- Malignant Neoplasm Of Breast
Interacting Proteins
- FIGNL1
- KRIT1
- NME2
Pathways
- Cell Adhesion
- Cell Proliferation
- Cell Migration
- Integrin Activation
- Angiogenesis
- Pathogenesis
- Cell Death
- Cell Motility
- Sprouting Angiogenesis
- Osteoblast Proliferation
- Localization
- Endothelial Cell Proliferation
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Cancer
- Cell Biology
- Cellular Markers
- Cytokine Research
- Immunology
- Mesenchymal Stem Cell Markers
- Neuronal Cell Markers
- Signal Transduction
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGB1BP1
bosterbio.com/bosterbio-gene-info-cards/ITGB1BP1
References
PMID: 9281591 by Chang D.D., et al. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin.
PMID: 9867804 by Zhang X.A., et al. Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 protein.