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Piwi-like protein 1 Antibodies
AND PIWIL1 ELISA kits, Piwi-like protein 1 Proteins
Many biological assays use antibodies to detect Piwi-like protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Piwi-like protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Piwi-like protein 1 antibodies...
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PIWIL1 Overview
Facts about Piwi-like protein 1.
Piwi-like protein 1 (PIWIL1)
Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.
Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are made by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their manual (g1U taste, also named 1U-bias).
Gene Information
| Human | |
|---|---|
| Gene Name: | PIWIL1 |
| Uniprot: | Q96J94 |
| Entrez: | 9271 |
Family
| Belongs to: |
|---|
| argonaute family |
Alternative Names
HIWI; HIWIpiwi homolog; MIWI; piwi (Drosophila)-like 1; PIWI; PIWIL1; piwi-like 1 (Drosophila); piwi-like protein 1
Molecular Weight
Mass (kDA):
98.603 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.33 |
| Sequence: | 12; NC_000012.12 (130337887..130412708) |
Tissue Specificity
Expressed in spermatocytes and spermatids. Also detected in prostate cancer (at protein level). Detected in most fetal and adult tissues. Expressed in testes, specifically in germline cells; detected in spermatocytes and spermatids during spermatogenesis. Increased expression in testicular tumors originating from embryonic germ cells with retention of germ cells phenotype. No expression in testicular tumors of somatic origin, such as Sertoli cell and Leydig cell tumors. Overexpressed in gastric cancer cells. Isoform 3: Ubiquitously expressed, and specifically in CD34(+) hematopoietic progenitor cells but not in more differentiated cells.
Subcellular Localizations
Cytoplasm. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body.
Diseases
- Neoplasms
- Malignant Neoplasms
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
- Metastatic Malignant Neoplasm To The Lymph Node
- Carcinoma
- Infertility
- Adenocarcinoma
- Carcinogenesis
- Stomach Neoplasms
- Sarcoma
- Malignant Paraganglionic Neoplasm
- Cell Invasion
Interacting Proteins
- DICER1
- SND1
Pathways
- Spermatogenesis
- Methylation
- Dna Methylation
- Meiosis
- Localization
- Pachytene
- Rna Interference
- Gene Silencing
- Stem Cell Maintenance
- Translation
- Cell Cycle
- Cell Differentiation
- Prophase
PTMs
- Methylation
- Cleavage
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIWIL1
bosterbio.com/bosterbio-gene-info-cards/PIWIL1
References
PMID: 11154219 by Sharma A.K., et al. Human CD34+ stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi.
PMID: 12037681 by Qiao D., et al. Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas.