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- Table of Contents
1 Citations 5 Q&As
Facts about Integrin alpha-6.
Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is vital for NRG1-ERBB signaling (PubMed:20682778).
Human | |
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Gene Name: | ITGA6 |
Uniprot: | P23229 |
Entrez: | 3655 |
Belongs to: |
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integrin alpha chain family |
CD49 antigen-like family member F; CD49f antigen; CD49f; DKFZp686J01244; FLJ18737; Integrin alpha 6; integrin alpha-6; integrin alpha6B; integrin, alpha 6; ITGA6; ITGA6B; Platelet gpl; VLA-6
Mass (kDA):
126.606 kDA
Human | |
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Location: | 2q31.1 |
Sequence: | 2; NC_000002.12 (172427336..172506459) |
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor.
PMID: 1976638 by Tamura R.N., et al. Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.
PMID: 2070796 by Hogervorst F., et al. Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes.
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