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- Table of Contents
Facts about Ras GTPase-activating-like protein IQGAP1.
It partners with calmodulin. Could function as a meeting scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton in the plasma membrane.
Human | |
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Gene Name: | IQGAP1 |
Uniprot: | P46940 |
Entrez: | 8826 |
Belongs to: |
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No superfamily |
HUMORFA01; IQ motif containing GTPase activating protein 1; IQGAP1; KIAA0051ras GTPase-activating-like protein IQGAP1; p195; p195RasGAP-like with IQ motifs; SAR1
Mass (kDA):
189.252 kDA
Human | |
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Location: | 15q26.1 |
Sequence: | 15; NC_000015.10 (90388242..90502239) |
Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
Cell membrane. Nucleus. Cytoplasm. Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816).
PMID: 8051149 by Weissbach L., et al. Identification of a human rasGAP-related protein containing calmodulin-binding motifs.
PMID: 15355962 by Grohmanova K., et al. Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator.