Importin-8 (IPO8)

Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is considered to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates via the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism.

At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported in the nucleus into the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.