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- Table of Contents
Facts about Indolethylamine N-methyltransferase.
Catalyzes the N-methylation of tryptamine and structurally related compounds. .
Human | |
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Gene Name: | INMT |
Uniprot: | O95050 |
Entrez: | 11185 |
Belongs to: |
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class I-like SAM-binding methyltransferase superfamily |
Amine N-methyltransferase; Aromatic alkylamine N-methyltransferase; Arylamine N-methyltransferase; EC 2.1.1; EC 2.1.1.49; Indolamine N-methyltransferase; indolethylamine N-methyltransferase; MGC125940; MGC125941; nicotine N-methyltransferase
Mass (kDA):
28.891 kDA
Human | |
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Location: | 7p14.3 |
Sequence: | 7; NC_000007.14 (30752135..30757602) |
Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain.
Cytoplasm.
PMID: 10552930 by Thompson M.A., et al. Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization.
PMID: 15014171 by Kitano T., et al. Human-specific amino acid changes found in 103 protein-coding genes.