Interleukin-19 Antibodies

Interleukin-19 (IL19)

May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).

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Gene Information

Human
Gene Name:	IL19
Uniprot:	Q9UHD0
Entrez:	29949

Family

Belongs to:
IL-10 family

Alternative Names

IL-10C; IL19; IL-19; interleukin 19; MDA1; melanoma differentiation associated protein-like protein; NG.1Melanoma differentiation-associated protein-like protein; ZMDA1interleukin-19

Molecular Weight

Mass (kDA):
20.452 kDA

Genomic Context

Human
Location:	1q32.1
Sequence:	1; NC_000001.11 (206770773..206842981)

Subcellular Localizations

Secreted.

Diseases

• Psoriasis
• Inflammation
• Arthritis
• Asthma
• Autoimmune Diseases
• Autoimmune Reaction
• Neoplasms
• Rheumatoid Arthritis
• Dysequilibrium Syndrome
• Inflammatory Response
• Inflammatory Bowel Diseases
• Melanoma
• Intestinal Diseases

• Carcinoma
• Decreased Immunologic Activity [pe]
• Colitis
• Hepatitis
• Atherosclerosis
• Systemic Inflammatory Response Syndrome
• Hyperplasia

Pathways

• Pathogenesis
• Cytokine Production
• Immune Response
• Inflammatory Response
• Secretion
• Cell Migration
• Cytokine Secretion
• Pigmentation
• Chemotaxis
• Cell Proliferation
• Keratinocyte Proliferation
• Muscle Cell Migration
• Chemokine Production

• Tube Formation
• Dna Demethylation
• Keratinocyte Differentiation
• Cell Motility
• Innate Immune Response
• Epithelial Cell Proliferation
• Smooth Muscle Cell Migration

PTMs

• Phosphorylation
• Demethylation

• Reduction
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL19

Best Uses Of The IL19 Marker For Fibrosis

This article focuses upon the IL19 Marker and its use for fibrosis. Learn more about this marker and how it's used in combination with other markers. It's a very accurate indicator of fibrosis, which you may be surprised to learn. This marker can be used in combination with other markers to increase your results. Here are some examples.

IL19 Marker

The IL19 indicator is one the most common proteins in immunology. Researchers can use it for multiple applications including identifying the presence of cancer cells. The best uses are many and include detection of a wide range of cancer cells, cytokines or chemokines. However, a lot of questions still surround the best ways to use this marker in different research applications.

The IL19 Marker is a marker for fibrosis

IL19, a fibrosis marker has been associated with lung cancer and many other diseases. This cytokine regulates cell growth and maturation through the TGF/Smad signaling pathway. Researchers have discovered a number of studies linking IL-19 to fibrosis. They hope this will one day prove to to be a therapeutic target.

This cytokine is inducible by inflammation and has been implicated with many diseases, including lung Fibrosis and Psoriasis. It is also implicated as a mediator of inflammatory diseases, such as breast and kidney disease. IL-19, which is produced in mice, induces angiogenesis by stimulating neutrophil chemotaxis and activating endothelial tissues. It may also act as a tissue-derived inflammatory mediator.

Another cytokine IL-24 is associated with liver fibrosis. However, it is also expressed in healthy tissue. IL-24 expression is lower in fibrotic tissue than it is in nonfibrotic tissues. Interestingly, both IL-24 and IL-20 have a protective role in liver homeostasis. These two cytokines may therefore have different functions.

IL-4 is a vital marker for cardiovascular disease. This can be used in the diagnosis of fibrosis. It has been shown that the levels of IL-4 in the urine correlate with markers of cardiac fibrosis and heart failure. Researchers also found a link between left ventricular ejection volume and urinary IL-4 in patients with heart failure.

In addition to IL-19, IL-20, and IL-24 have also been shown to be involved in renal disease. The expression levels of these three molecules were measured in human biopsies. Researchers also looked at the kidneys from mice with UUO to determine if IL-20RB was expressed. These mice also contained IL-24. These findings indicate that IL-20RB may be associated with fibrosis.

IBD is characterized by high levels of IL-24 (inflammation-associated inflammatory bowel disease) in the colon. Although it is not clear what role it plays in asthma pathogenesis, the findings from this marker suggest that it could be a promising therapeutic target. The protocol for this study was approved by the National Cheng Kung University and followed National Institutes of Health guidelines. To determine its role in the development and progression of asthma, further studies will be required.

The IL19 marker may be used with other markers

The IL19 Marker could be used together with other markers to detect infections. This is important because markers for viral and bacterial infections overlap to varying degrees, and their cut-off values and detection methods vary. As such, using any one of the markers as a diagnostic test alone may not prove to be the best option. A combination of markers with one another can greatly increase the predictive accuracy.

The results were also replicated with patients with atopic-dermatitis, a common skin disease that causes severe skin inflammation. Atopic Dermatitis is a widespread condition that affects a wide range age groups and is highly prevalent worldwide. Further, IL-19 may be used in combination with other markers in the diagnosis of atopic dermatitis.