Interleukin-10 receptor subunit beta (IL10RB)

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity.

The ligand/receptor complex stimulate the activation of this JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. .