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Ikzf3 Antibodies
AND Ikzf3 ELISA kits, Ikzf3 Proteins
Many biological assays use antibodies to detect Ikzf3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ikzf3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ikzf3 antibodies...
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Ikzf3 Infographic by Boster Bio
All Ikzf3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M01611-1
100 µl
Cat # M01611-1
100 µl
Human, Mouse, Rat
IHC, WB
$523
Cat # M01611
100 µl
Cat # M01611
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01611-2
100 μl/vial
Cat # M01611-2
100 μl/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01611-2
100 µg/vial
Cat # A01611-2
100 µg/vial
Ikzf3 Overview
Facts about Zinc finger protein Aiolos.
Zinc finger protein Aiolos (Ikzf3)
Transcription factor that plays a significant role in the regulation of lymphocyte differentiation. Binds to GGGAA.
Plays an important role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells within an IL2-dependent method.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Ikzf3 |
| Uniprot: | O08900 |
| Entrez: | 22780 |
Family
| Belongs to: |
|---|
| Ikaros C2H2-type zinc-finger protein family |
Alternative Names
AIO; Aiolos; IKAROS family zinc finger 3 (Aiolos); Ikaros family zinc finger protein 3; IKZF3; zinc finger protein Aiolos; ZNFN1A3; ZNFN1A3subfamily 1A, 3 (Aiolos)
Molecular Weight
Mass (kDA):
57.967 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 11|11 D |
| Sequence: | 11; |
Tissue Specificity
Expression is restricted to lymphoid tissues. Expressed at highest levels in spleen and at lower levels in the thymus and bone marrow. First detected in more committed lymphoid progenitors and strongly up-regulated as these differentiate into pre-T and pre-B cell precursors.
Diseases
- Leukemia
- Lymphoma
- Malignant Neoplasms
- Neoplasms
- Acute Lymphocytic Leukemia
- Autoimmune Diseases
- Autoimmune Reaction
- Lupus Erythematosus, Systemic
- Biliary Cirrhosis
- Primary Biliary Cirrhosis
- Liver Cirrhosis
- Chronic Lymphocytic Leukemia
- B-cell Lymphomas
Pathways
- Lymphocyte Differentiation
- Cell Development
- Cell Differentiation
- B Cell Differentiation
- Cell Activation
- Localization
- Plasma Cell Differentiation
- B Cell Activation
- Cell Cycle
- Oncogenesis
- Chromatin Remodeling
- Cell Death
- Cellular Localization
PTMs
- Phosphorylation
- Methylation
Research Areas
- Chromatin Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ikzf3
bosterbio.com/bosterbio-gene-info-cards/Ikzf3
References
PMID: 9155026 by Morgan B., et al. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.
PMID: 9806640 by Wang J.H., et al. Aiolos regulates B cell activation and maturation to effector state.