IFT57 Antibodies

AND IFT57 ELISA kits, IFT57 Proteins

Many biological assays use antibodies to detect IFT57, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IFT57 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IFT57 antibodies...

We validate the specificity of these antibodies to IFT57 by testing them on tissues known to express IFT57 positively and negatively. Browse below to find the IFT57 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IFT57 Infographic by Boster Bio

All IFT57 Products

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Product

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Specificity

Applications

Price

Anti-IFT57 Antibody

Human, Mouse, Rat

$405
Cat # A07455
100ul

Anti-HIPPI (IFT57) Mouse Monoclonal Antibody [Clone ID: OTI4F6]

Human, Mouse, Rat

IF, IHC, WB

$523
Cat # M07455
100 µl

HIPPI (IFT57) (NM_018010) Human Over-expression Lysate

Human

$628
Cat # LS055081
100 µg

IFT57 Overview

Facts about Intraflagellar transport protein 57 homolog.

IFT57 3D structure. Source: alphafold

Intraflagellar transport protein 57 homolog (IFT57)

Required for the formation of cilia.
Plays an indirect part in sonic hedgehog signaling, cilia needing all activity of the hedgehog pathway (By similarity).

Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and activate apoptosis. Has the capacity to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes like CASP1, CASP8 and CASP10, suggesting that it may function as a transcription regulator; however the significance of such function remains unclear.

Gene Information

Human
Gene Name:	IFT57
Uniprot:	Q9NWB7
Entrez:	55081

Family

Belongs to:

IFT57 family

Alternative Names

Dermal papilla-derived protein 8; DERP8; ESRRBL1huntingtin interacting protein-1 interacting protein; estrogen-related receptor beta like 1; Estrogen-related receptor beta-like protein 1; FLJ10147; HIPPIHIP1-interacting protein; intraflagellar transport 57 homolog (Chlamydomonas); intraflagellar transport protein 57 homolog; MHS4R2HIP1 protein interactor

Molecular Weight

Mass (kDA):
49.108 kDA

Genomic Context


Human

Location:	3q13.12-q13.13
Sequence:	3; NC_000003.12 (108160812..108222424, complement)

Tissue Specificity

Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level).

Subcellular Localizations

Cytoplasm, cytoskeleton, cilium basal body. Concentrates within the inner segment of cilia.

Diseases

Huntington Disease
Neoplasms
Retinal Degeneration
Neurodegenerative Disorders
Von Hippel-lindau Syndrome
Monoclonal Gammapathies
Paraproteinemias
Hypoxia
Monoclonal Gammopathy Of Undetermined Significance
Multiple Myeloma
Tumor Angiogenesis

Malignant Neoplasms
Nervousness
Pathologic Neovascularization
Abnormal Degeneration
Cell Transformation, Neoplastic
Leukemia, Experimental

Interacting Proteins

BLOC1S2
ZDHHC17

Pathways

Transport
Intraflagellar Transport
Localization
Pathogenesis
Induction Of Apoptosis
Clathrin-mediated Endocytosis
Fertilization
Immune Response
Endocytosis
Protein Transport

Cell Death
Lipid Homeostasis
Synapse Assembly
Angiogenesis
Glycolysis

PTMs

Phosphorylation

Cleavage

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IFT57

References

PMID: 11788820 by Gervais F.G., et al. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

PMID: 12745083 by Cheng C.-M., et al. The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1.