Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (IDH3A)

Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full action of the heterotetramer (containing two subunits of IDH3A, among IDH3B and among IDH3G) requires the assembly and cooperative function of both heterodimers.

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