HIPK3 Antibodies

AND HIPK3 ELISA kits, HIPK3 Proteins

Many biological assays use antibodies to detect HIPK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HIPK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HIPK3 antibodies...

We validate the specificity of these antibodies to HIPK3 by testing them on tissues known to express HIPK3 positively and negatively. Browse below to find the HIPK3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HIPK3 Infographic by Boster Bio

All HIPK3 Products

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Product

Figures

Specificity

Applications

Price

Anti-HIPK3 Antibody

Human

ELISA, WB

$380
Cat # A09462
100ul

HIPK3 (NM_005734) Human Over-expression Lysate

Human

$960
Cat # LS010114
100 µg

HIPK3 Overview

Facts about Homeodomain-interacting protein kinase 3.

HIPK3 3D structure. Source: alphafold

Homeodomain-interacting protein kinase 3 (HIPK3)

Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2.

Appears to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription.

Gene Information

Human
Gene Name:	HIPK3
Uniprot:	Q9H422
Entrez:	10114

Family

Belongs to:

protein kinase superfamily

Alternative Names

Androgen receptor-interacting nuclear protein kinase; DYRK6Fas-interacting serine/threonine-protein kinase; EC 2.7.11.1; FIST; FIST3ANPK; homeodomain interacting protein kinase 3; homeodomain-interacting protein kinase 3; PKYHomolog of protein kinase YAK1; YAK1

Molecular Weight

Mass (kDA):
133.743 kDA

Genomic Context


Human

Location:	11p13
Sequence:	11; NC_000011.10 (33256672..33357023)

Tissue Specificity

Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Leukemia
Lung Diseases
Carcinoma
Lung Diseases, Obstructive
Chronic Obstructive Airway Disease
Osteosarcoma
Diabetes Mellitus
Prostatic Neoplasms
Myocardial Ischemia
Leukoencephalopathy, Progressive Multifocal

Dyslipidemias
Leukemia, Radiation-induced
Leukemia, T-cell
Bone Neoplasms
Down Syndrome
Myeloid Leukemia, Chronic
Bronchitis, Chronic

Pathways

Transport
Response To Camp
Cellular Ion Homeostasis
Chemotaxis
Cell Cycle
Hemostasis
Dna Methylation
Protein Transport
Ion Homeostasis
Methylation
Coagulation
Cell Death
Rna Interference

Lymphocyte Activation
Protein Phosphorylation
Sex Determination
Cell Cycle Arrest
Spermatogenesis
Cytokinesis
Cell Proliferation

PTMs

Phosphorylation
Methylation

Sumoylation
Ubiquitination

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HIPK3

References

PMID: 9373137 by Begley D.A., et al. Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1.

PMID: 11034606 by Rochat-Steiner V., et al. FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun NH2- terminal kinase activation.