Protein fem-1 homolog B Antibodies

AND FEM1B ELISA kits, Protein fem-1 homolog B Proteins

Many biological assays use antibodies to detect Protein fem-1 homolog B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein fem-1 homolog B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein fem-1 homolog B antibodies...

We validate the specificity of these antibodies to Protein fem-1 homolog B by testing them on tissues known to express FEM1B positively and negatively. Browse below to find the FEM1B antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FEM1B Infographic by Boster Bio

All FEM1B Products

Product

Figures

Specificity

Applications

Price

Anti-F1A alpha FEM1B Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A07467
0.1 mg

FEM 1B (FEM1B) (NM_015322) Human Recombinant Protein

$1249
Cat # PROTQ9UK73
20 µg

FEM 1B (FEM1B) (NM_015322) Human Over-expression Lysate

Human

$628
Cat # LS010116
100 µg

FEM1B Overview

Facts about Protein fem-1 homolog B.

FEM1B 3D structure. Source: alphafold

Protein fem-1 homolog B (FEM1B)

Part of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a departure receptor-associated protein that mediates apoptosis.

Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that contributes to the activation of CHEK1.

Gene Information

Human
Gene Name:	FEM1B
Uniprot:	Q9UK73
Entrez:	10116

Family

Belongs to:

fem-1 family

Alternative Names

DKFZp451E0710; F1AA; F1A-alpha; FEM-1 (C.elegans) homolog b; fem-1 homolog b (C. elegans); FEM1b; FEM1-beta; FEM-1-like death receptor binding protein; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; FIAA; KIAA0396; protein fem-1 homolog B

Molecular Weight

Mass (kDA):
70.264 kDA

Genomic Context


Human

Location:	15q23
Sequence:	15; NC_000015.10 (68277745..68295862)

Tissue Specificity

Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.

Subcellular Localizations

Cytoplasm. Nucleus. In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.

Diseases

Malignant Neoplasms
Colonic Neoplasms
Malignant Tumor Of Colon
Polycystic Ovary Syndrome
Neoplasms
Feminization
Von Hippel-lindau Syndrome
Malignant Paraganglionic Neoplasm
Tissue Adhesions
Bardet-biedl Syndrome
Diabetes Mellitus
Intestinal Neoplasms

Carcinogenesis
Insulin Resistance
Diabetes Mellitus, Non-insulin-dependent
Adenomatous Polyposis Coli
Nervousness
Polyposis
Colorectal Cancer

Interacting Proteins

HIF1AN
PPM1F

Pathways

Sex Determination
Pathogenesis
Induction Of Apoptosis
Insulin Secretion
Secretion
Transport
Hepatocyte Differentiation
Localization
Spermatogenesis
Glucose Homeostasis
Regeneration

Flight
Dna Replication
Cell Death
Cell Growth
Meiosis
Tissue Homeostasis

PTMs

Ubiquitination

Phosphorylation

Cleavage

Research Areas

Apoptosis
Cancer
Cell Biology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FEM1B

References

PMID: 10542291 by Chan S.-L., et al. F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis.

PMID: 10623617 by Ventura-Holman T., et al. Sequence, organization, and expression of the human FEM1B gene.