Homeodomain-interacting protein kinase 2 (Hipk2)

Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, such as SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors.

Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both in the transcription level and at the protein level (by phosphorylation and indirect acetylation).