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- Table of Contents
Facts about 5-hydroxytryptamine receptor 1E.
Ligand binding causes a conformation change that activates signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Human | |
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Gene Name: | HTR1E |
Uniprot: | P28566 |
Entrez: | 3354 |
Belongs to: |
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G-protein coupled receptor 1 family |
5HT1E; 5-HT1E; 5-HT-1E; 5-hydroxytryptamine (serotonin) receptor 1E; HTR1E; S31; S31,5-HT1E5-hydroxytryptamine receptor 1E; Serotonin receptor 1E
Mass (kDA):
41.682 kDA
Human | |
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Location: | 6q14.3 |
Sequence: | 6; NC_000006.12 (86936919..87020068) |
Detected in brain.
Cell membrane; Multi-pass membrane protein.
PMID: 1608964 by McAllister G., et al. Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype.
PMID: 1733778 by Levy F.O., et al. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase.